Article
Sequence elements correlating with circulating viral load in genotype 1b hepatitis C virus infection.
Virology - 5 Jul 2003
Watanabe Hideki, Nagayama Kazuyoshi, Enomoto Nobuyuki, Itakura Jun, Tanabe Yoko, Hamano Kosei, Izumi Namiki, Sato Chifumi, Watanabe Mamoru
Abstract excerpt
The correlation between hepatitis C virus (HCV) genomic sequences and circulating HCV RNA levels was assessed to investigate the genetic elements affecting viral load. The interferon sensitivity-determining region (ISDR) sequence and the serum viral load were strongly correlated in 226 patients examined. Analysis of the entire HCV genome from six patients (three with a high and the others with a low viral load)...
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