Article
Fluctuations of hepatitis C virus load are not related to amino acid substitutions in hypervariable region 1 and interferon sensitivity determining region.
Journal of medical virology - 1 Jul 1999
Hashimoto M, Chayama K, Kobayashi M, Tsubota A, Arase Y, Saitoh S, Suzuki Y, Ikeda K, Matsuda M, Koike H, Kobayashi M, Handa H, Kumada H
Abstract excerpt
Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up. Virus load, determined by a branched chain DNA amplification assay, was stable in 73 of 78 (93.6%) patients,...
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