Article
Preventive surgery is associated with reduced cancer risk and mortality in women with BRCA1 and BRCA2 mutations.
LDI issue brief - 1 Jan 2000
Domchek Susan M, Rebbeck Timothy R
Abstract excerpt
Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have a substantially elevated risk of developing breast and ovarian cancer. For more than 10 years, researchers have studied whether preventive surgery (to remove breasts, ovaries, and/or fallopian tubes) can reduce the cancer and mortality risk in BRCA1/2 mutation carriers. This Issue Brief summarizes the results of the latest, largest,...
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