Article
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
The Journal of biological chemistry - 19 Sept 2003
Singh Saurabh, Powell David W, Rane Madhavi J, Millard Tom H, Trent John O, Pierce William M, Klein Jon B, Machesky Laura M, McLeish Kenneth R
Abstract excerpt
The p38 MAPK pathway regulates multiple neutrophil functional responses via activation of the serine-threonine kinase MAPK-activated protein kinase 2 (MAPKAPK2). To identify substrates of MAPKAPK2 that mediate these responses, a proteomic approach was used in which in vitro phosphorylation of neutrophil lysates by exogenously added active recombinant MAPKAPK2 was followed by protein separation using...
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