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Article

PrtT-regulated proteins secreted by Aspergillus fumigatus activate MAPK signaling in exposed A549 lung cells leading to necrotic cell death.

PloS one - 11 Mar 2011

Sharon Haim, Amar David, Levdansky Emma, Mircus Gabriel, Shadkchan Yana, Shamir Ron, Osherov Nir

Abstract excerpt

Aspergillus fumigatus is the most commonly encountered mold pathogen of humans, predominantly infecting the respiratory system. Colonization and penetration of the lung alveolar epithelium is a key but poorly understood step in the infection process. This study focused on identifying the transcriptional and cell-signaling responses activated in A549 alveolar carcinoma cells incubated in the presence of A....

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Identifiers

PMID: 21412410
DOI: 10.1371/journal.pone.0017509
PMCID: PMC3055868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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