Article
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity.
Nature genetics - 1 Nov 1998
Deeb S S, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J
Abstract excerpt
The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a transcription factor that has a pivotal role in adipocyte differentiation and expression of adipocyte-specific genes. The PPARgamma1 and gamma2 isoforms result from alternative splicing and have ligand-dependent and -independen...
Topics
- Adult
- Aged
- Alleles
- Amino Acid Substitution
- Base Sequence
- Body Mass Index
- DNA Primers
- Diabetes Mellitus, Type 2
- Female
- Finland
- Gene Frequency
- Genetic Variation
- Genotype
- Humans
- Insulin Resistance
- Male