Article
Effect of a Tyr-to-His point-mutation at position 59 in the alpha-1 helix of the HLA-B27 class-I molecule on allospecific and virus-specific cytotoxic T-lymphocyte recognition.
Scandinavian journal of rheumatology. Supplement - 1 Jan 1990
Breur-Vriesendorp B S, Vingerhoed J, Kuijpers K C, van der Horst A R, de Waal L P, Kievits F, Ivanyi P
Abstract excerpt
HLA-B2703, a mutation of HLA-B2705, is characterized by a Tyr-to-His substitution at position 59 in the alpha 1 domain of the class-I heavy chain. So far, the HLA-B2703 subtype was found only in two Black individuals and it is the first polymorphism at position 59 of MHC class-I molecules. We have examined whether the single amino-acid substitution at position 59 results in an alloantigenic determinant and...
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