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Article

Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.

Antimicrobial agents and chemotherapy - 1 Jul 2013

James Scott H, Price Nathan B, Hartline Caroll B, Lanier E Randall, Prichard Mark N

Abstract excerpt

CMX001 is an orally available lipid acyclic nucleotide phosphonate that delivers high intracellular levels of cidofovir (CDV)-diphosphate and exhibits enhanced in vitro antiviral activity against a wide range of double-stranded DNA viruses, including cytomegalovirus (CMV). Mutations in the DNA polymerase of CMV that impart resistance to CDV also render the virus resistant to CMX001. Here, we report a novel...

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Identifiers

PMID: 23650158
DOI: 10.1128/AAC.00062-13
PMCID: PMC3697342

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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