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Article

Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2008

Chou Sunwen, Marousek Gail, Li Shaobing, Weinberg Adriana

Abstract excerpt

BACKGROUND: Diverse mutations in the cytomegalovirus (CMV) DNA polymerase (pol) gene confer resistance to one or more of the antiviral drugs ganciclovir, foscarnet or cidofovir. The levels of resistance conferred by specific mutations are variable, ranging from insignificant resistance to triple-drug resistance. OBJECTIVES: Three pol mutations, I521T, P522A and P522L, detected in patients who received antiviral...

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Source

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Identifiers

PMID: 18502683
DOI: 10.1016/j.jcv.2008.04.005
PMCID: PMC2576411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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