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Article

The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease.

Brain research - 24 Jan 2003

Liu Hsing-Cheng, Leu Sy-Jye, Chang Jan-Gowth, Sung Shing-Ming, Hsu Wei-Chen, Lee Long-Shyong, Hu Chaur-Jong

Abstract excerpt

The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphisms of cDNA in 25 AD patients and 100 healthy controls by single-strand conformational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12535780
DOI: 10.1016/s0006-8993(02)03849-0

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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