Article
Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease.
Neurogenetics - 1 Oct 2001
Nicolaou M, Song Y Q, Sato C A, Orlacchio A, Kawarai T, Medeiros H, Liang Y, Sorbi S, Richard E, Rogaev E I, Moliaka Y, Bruni A C, Jorge R, Percy M, Duara R, Farrer L A, St Georg-Hyslop P, Rogaeva E A
Abstract excerpt
Amyloid beta-peptide (Abeta) plays a central role in the pathogenesis of Alzheimer's disease (AD). The gene encoding the beta-site APP cleaving enzyme (BACE), one of two enzymes that sequentially cleave the beta-amyloid precursor protein to generate Abeta, has recently been cloned. We tested the hypothesis that BACE might be genetically associated with AD by linkage analysis (56 pedigrees), by direct nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.