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Article

Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.

Neuroscience letters - 2 Nov 2001

Cruts M, Dermaut B, Rademakers R, Roks G, Van den Broeck M, Munteanu G, van Duijn C M, Van Broeckhoven C

Abstract excerpt

The beta-site of beta-amyloid precursor protein cleaving enzyme (BACE) cleaves the beta-amyloid (Abeta) precursor protein at the N-terminal end of Abeta, allowing for the production of Abeta by C-terminal gamma-secretase cleavage. We hypothesized that over-activity of BACE might lead to the overp...

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Source

Identifiers

PMID: 11684351
DOI: 10.1016/s0304-3940(01)02234-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11684351-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Amyloid beta secretase gene (BACE) is neither mutated in nor associated with early-onset Alzheimer's disease.PMID 11684351Read ↗

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