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Article

In vitro analysis of the antileukemic effect of tumor necrosis factor-alpha gene therapy with myeloid progenitor cells: the role of dendritic cells.

Journal of experimental therapeutics & oncology - 1 Jan 2000

Xu Yong X, Deeb Dorrah, Gao Xiaohua, Janakiraman Nalini, Chapman Robert A, Gautam Subhash C

Abstract excerpt

We have previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) gene therapy with transgene-expressing myeloid progenitor cells (32DTNF-alpha) is effective in inhibiting the progression of leukemia with a lethal dose of murine 32Dp210 myeloid leukemia cells. Because TNF-alpha has been shown to induce the activation and maturation of dendritic cells (DCs), we investigated the effect of TNF-alpha...

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Source

Identifiers

PMID: 12822512
DOI: 10.1046/j.1359-4117.2003.01069.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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