Article
IL-12 increases CD80 expression and the stimulatory capacity of bone marrow-derived dendritic cells.
International immunology - 1 Jun 1998
Kelleher P, Knight S C
Abstract excerpt
Dendritic cells (DC) are potent antigen-presenting cells derived from CD34 bone marrow stem cells. They undergo a series of maturational steps that allow them to stimulate primary T cell responses. Several cytokines are known to contribute to this process. In this study murine DC maturing from bone marrow progenitors under the influence of granulocyte macrophage colony stimulating factor and tumour necrosis...
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