Article
In vivo generation of dendritic cells by intramuscular codelivery of FLT3 ligand and GM-CSF plasmids.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Sept 2002
Peretz Yoav, Zhou Zheng Frank, Halwani Fawaz, Prud'homme Gérald J
Abstract excerpt
Dendritic cells (DCs) are the major cells responsible for the uptake and the transport of antigens to regional lymphoid tissues and for the presentation of antigenic peptides to T cells. They are highly effective in immunotherapy. However, in lymphoid and other tissues, DCs constitute only a small population and are difficult to isolate in large numbers. Our objective was to devise a method with which to rapidly...
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