Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

Oncogene - 26 Jun 2003

Krasilnikov Mikhail, Ivanov Vladimir N, Dong Jinali, Ronai Ze'ev

Abstract excerpt

Signal transducers and activators of transcription (STAT) proteins nuclear translocation and transcriptional activity are regulated by diverse protein kinases in response to extracellular stimuli by cytokines, growth factors and stress. Using two melanoma-derived cell lines that exhibit marked differences in basal activities of MAPKs and PI3K-AKT, we studied changes both in STAT activities and in their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Chromones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flavonoids

Share to Milk Proteins

Share to Morpholines

Share to STAT3 Transcription Factor

Share to STAT5 Transcription Factor

Share to TNF-Related Apoptosis-Inducing Ligand

Source

Identifiers

PMID: 12821943
DOI: 10.1038/sj.onc.1206598

Genes

JAK2
PTEN
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.PMID 12821943Read ↗

Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.Semantic proximity Read ↗

Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma.Semantic proximity Read ↗

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer.Semantic proximity Read ↗

PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cellsSemantic proximity Read ↗

The MAPK pathway as an apoptosis enhancer in melanomaSemantic proximity Read ↗

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.Semantic proximity Read ↗

The role of JAKs and STATs in chemoresistanceSemantic proximity Read ↗

PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells.Semantic proximity Read ↗

Oncogenic BRAFV600E inhibits BIM expression to promote melanoma cell survivalSemantic proximity Read ↗

Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway.Semantic proximity Read ↗

Loss of T-cadherin (CDH-13) regulates AKT signaling and desensitizes cells to apoptosis in melanomaSemantic proximity Read ↗

Fas-induced Apoptosis in Human Malignant Melanoma Cell Lines Is Associated with the Activation of the p34 -related PITSLRE Protein KinasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.