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Article

Fas-induced Apoptosis in Human Malignant Melanoma Cell Lines Is Associated with the Activation of the p34 -related PITSLRE Protein Kinases

1 Oct 1999

Abstract excerpt

The Cdc2L locus encoding the PITSLRE protein kinases maps to chromosome band 1p36 and consists of two duplicated and tandemly linked genes. The purpose of the present study was to determine whether diminution of PITSLRE kinases leads to deregulation of apoptosis. The human melanoma cell lines A375 (Cdc2L wild-type alleles) and UACC 1227 (mutant Cdc2L alleles) were tested with agonist anti-Fas monoclonal antibody....

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PMID: 10497214
DOI: 10.1074/jbc.274.40.28505

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