Article

The role of JAKs and STATs in chemoresistance

2010-01-01

Abstract excerpt

Janus kinases (JAKs) and Signal Transducer and Activators of Transcription (STATs) are essential for signalling in response to the Interferons (IFNs) and most cytokines. Aberrant activation of JAKs and/or STATs has been observed in many human cancer cells, and several recent studies have suggested that STAT3 oncogenic pathways are also associated with intrinsic drug resistance. Chemoresistance is a major cause of...

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Literature Corpus work: 7ed477e8-fb2c-591f-8e01-bf325b49b47e
DOI: 10.25560/10188

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