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Article

Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma.

Veterinary and comparative oncology - 1 Sept 2015

Fowles J S, Denton C L, Gustafson D L

Abstract excerpt

The lack of advanced animal models of human cancers is considered a barrier to developing effective therapeutics. Canine and human melanomas are histologically disparate but show similar disease progression and response to therapies. The purpose of these studies was to compare human and canine melanoma tumours and cell lines regarding MAPK and PI3K/AKT signalling dysregulation, and response to select molecularly...

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PMID: 23745794
DOI: 10.1111/vco.12044

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