Article
Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.
Oncogene - 27 Feb 2014
Becker T M, Boyd S C, Mijatov B, Gowrishankar K, Snoyman S, Pupo G M, Scolyer R A, Mann G J, Kefford R F, Zhang X D, Rizos H
Abstract excerpt
Approximately 50% of melanomas depend on mutant B-RAF for proliferation, metastasis and survival. The inhibition of oncogenic B-RAF with highly targeted compounds has produced remarkable albeit short-lived clinical responses in B-RAF mutant melanoma patients. Reactivation of signaling downstream of B-RAF is frequently associated with acquired resistance to B-RAF inhibitors, and the identification of B-RAF targets...
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