Article
High-risk genotype for type 1 diabetes: a new simple microtiter plate-based ELOSA assay.
Genetic testing - 1 Jan 2003
Geranton S, Rostagnat-Stefanutti A, Bendelac N, Cerrato E, Barbalat V, Leissner P, Nicolino M, Thivolet C, Mougin B
Abstract excerpt
The main contribution to genetic susceptibility for type 1 diabetes (T1D) is conferred by the HLA class II genes, with a major involvement of the DQB1*02 and 0302 alleles. The aim of our study was to develop a simple and rapid method suitable for identifying individuals with an HLA-associated T1D risk using whole blood as a source of DNA and reverse hybridization on microtiter plates (ELOSA). DNA was extracted...
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