Article
Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2006
Feng Joy Y, Myrick Florence T, Margot Nicolas A, Mulamba Gilbert B, Rimsky Laurence, Borroto-Esoda Katyna, Selmi Boulbaba, Canard Bruno
Abstract excerpt
Emtricitabine (FTC) and lamivudine (3TC) are deoxycytidine analogues with potent and selective inhibition of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) replication. The K65R mutation in the HIV reverse transcriptase (RT) confers reduced susceptibility to 3TC, ddC, ddI, abacavir, and tenofovir in vitro. The Q151M mutation confers reduced susceptibility to many of the approved anti-HIV...
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