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Article

A Possible Novel Mechanism of Action of Genistein and Daidzein for Activating Thyroid Hormone Receptor-Mediated Transcription.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2018

Ariyani Winda, Iwasaki Toshiharu, Miyazaki Wataru, Yu Lu, Takeda Shigeki, Koibuchi Noriyuki

Abstract excerpt

Thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily that regulate their target genes for controlling organ development and functional maintenance. Soybean isoflavones, especially genistein and daidzein, modulate various hormone-mediated pathways. However, their effects on TRs have not yet been extensively studied. In this study, the effects of these isoflavones on TR action were...

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PMID: 29688519
DOI: 10.1093/toxsci/kfy097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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