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ESE-1, an Enterocyte-specific Ets Transcription Factor, Regulates MIP-3α Gene Expression in Caco-2 Human Colonic Epithelial Cells

1 Jan 2003

Abstract excerpt

We have previously shown that colonic epithelial cells are a major site of MIP-3alpha production in human colon and that enterocyte MIP-3alpha protein levels are elevated in inflammatory bowel disease. The aim of this study was to determine the molecular mechanisms regulating MIP-3alpha gene transcription in Caco-2 intestinal epithelial cells. We show that a kappaB element at nucleotides -82 to -93 of the...

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PMID: 12414801
DOI: 10.1074/jbc.m208241200

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