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Article

A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients.

Atherosclerosis - 1 Apr 2003

Vendrell Joan, Fernandez-Real José Manuel, Gutierrez Cristina, Zamora Alberto, Simon Inmaculada, Bardaji Alfredo, Ricart Wifredo, Richart Cristobal

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a key cytokine in the inflammation process of atherosclerosis. Through its effects on lipid metabolism, insulin resistance and endothelial function, it might be involved in coronary heart disease (CHD). A biallelic polymorphism within the promoter of TNF-alpha locus at the position -308 has been reported to be associated with TNF production. We have studied...

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Identifiers

PMID: 12818408
DOI: 10.1016/s0021-9150(02)00429-x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients.PMID 12818408Read ↗

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