Article
Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women.
Cytokine - 1 Jan 2012
Gupta Vani, Gupta Abhishek, Jafar Tabrez, Gupta Vandana, Agrawal Suraksha, Srivastava Nidhi, Kumar Sandeep, Singh Arun K, Natu S M, Agarwal C G, Agarwal G G
Abstract excerpt
BACKGROUND: Tumour necrosis factor alpha is a multifunctional proinflammatory cytokine involved in the pathogenesis of metabolic syndrome, insulin resistance, and obesity. Aim of this study is to investigate in a North Indian female population the impact of the G-308A TNF-α variant on various components of the metabolic syndrome, Insulin Resistance, serum TNF-α and Leptin levels. METHODS: The G-308A TNF-α...
Topics
- Adult
- Anthropometry
- Case-Control Studies
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- India
- Insulin Resistance
- Leptin
- Metabolic Syndrome
- Odds Ratio
- Polymorphism, Single Nucleotide