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Article

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort.

Genes and immunity - 1 Jun 2002

Heijmans B T, Westendorp R G J, Droog S, Kluft C, Knook D L, Slagboom P E

Abstract excerpt

Ample evidence supports a role for tumour necrosis factor alpha (TNFalpha) in the development of type 2 diabetes and cardiovascular disease. TNFalpha expression was found to be influenced by a -308G/A polymorphism in the promoter of the gene encoding TNFalpha (TNF). We investigated the contribution of this polymorphism to diabetes and cardiovascular mortality in a population-based cohort of 664 subjects aged 85...

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Share to Aged
Share to Aged, 80 and over
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linkage Disequilibrium

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 12058258
DOI: 10.1038/sj.gene.6363859

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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