Costimulatory connections: CARMIL2 and CD28.

Abstract excerpt

In this issue of JEM, Zhang et al. (https://doi.org/10.1084/jem.20250339) report that a gain-of-function mutation in CARMIL2, previously identified in patients, is sufficient to replace the contribution of CD28 to NF-κB activation and downstream effects in T cells, including in the setting of an anti-tumor response.

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