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Article

A population perspective on multistage carcinogenesis.

Princess Takamatsu symposia - 1 Jan 1991

Moolgavkar S H

Abstract excerpt

The concept of multistage carcinogenesis is one of the central dogmas of cancer research today. Recent laboratory work suggests that many specific genetic changes are associated with carcinogenesis. At the same time, there is increasing evidence that cell proliferation kinetics are important in carcinogenesis. In 1971, Knudson proposed his now celebrated two-mutation model for embryonal tumors. In fact, a...

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PMID: 1668893

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FAP

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