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Article

Genetic variation in cancer predisposition: mutational decay of a robust genetic control network.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2004

Frank Steven A

Abstract excerpt

A computational model of cancer progression is used to study how mutations in genes that control tumor initiation and progression accumulate in populations. The model assumes that cancer occurs only after a cell lineage has progressed through a series of stages. The greater the number of stages, the more strongly the individual is protected against cancer. It is shown that an extra stage initially improves the...

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Identifiers

PMID: 15141087
DOI: 10.1073/pnas.0400561101
PMCID: PMC419557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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