Article
[Functional interactions of the influenza virus glycoproteins].
Molekuliarnaia biologiia - 1 Jan 2000
Rudneva I A, Il'iushina N A, Shilov A A, Varich N L, Sinitsyn B V, Kropotkina E A, Kaverin N V
Abstract excerpt
Hemagglutinin (HA) and neuraminidase (NA) are functionally related coat glycoproteins of the influenza virus (Flu). HA interacts with terminal sialyl residues of oligosaccharides and ensures the binding of the virus particle to the cell surface. NA is a receptor-destroying enzyme that removes sialyl residues from oligosaccharides contained in cell and virus components and thereby prevents aggregation of virus...
Topics
- Amino Acid Substitution
- Animals
- Birds
- Evolution, Molecular
- Hemagglutinin Glycoproteins, Influenza Virus
- Mutation
- Neuraminidase
- Oligosaccharides
- Orthomyxoviridae