Article
Effects of host-dependent glycosylation of hemagglutinin on receptor-binding properties on H1N1 human influenza A virus grown in MDCK cells and in embryonated eggs.
Virology - 1 Aug 1998
Gambaryan A S, Marinina V P, Tuzikov A B, Bovin N V, Rudneva I A, Sinitsyn B V, Shilov A A, Matrosovich M N
Abstract excerpt
There is growing evidence that the receptor-binding characteristics of influenza viruses are affected by the host-dependent glycosylation of viral hemagglutinin (HA). To better understand these effects, we propagated two variants of the human influenza virus USSR/90/77 (which differed by the muta...
Topics
- Animals
- Binding Sites
- Cells, Cultured
- Chickens
- Dogs
- Glycosylation
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A Virus, H1N1 Subtype
- Influenza A virus
- Models, Molecular
- Mutation
- Ovum
- Receptors, Virus
- Solubility