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Article

Cancer drugs, genetic variation and the glutathione-S-transferase gene family.

American journal of pharmacogenomics : genomics-related research in drug development and clinical practice - 1 Jan 2003

Townsend Danyelle, Tew Kenneth

Abstract excerpt

The glutathione-S-transferase (GST) super family comprises multiple isozymes (Alpha, Mu, Pi, Omega, Theta, and Zeta) with compelling evidence of functional polymorphic variation. Over the last two decades, a significant body of data has accumulated linking aberrant expression of GST isozymes with the development and expression of resistance to cancer drugs. Clinical correlation studies show that genetic...

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Identifiers

PMID: 12814324
DOI: 10.2165/00129785-200303030-00002
PMCID: PMC9086716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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