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Article

The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.

The Journal of biological chemistry - 5 Sept 2003

Rodriguez-Hernandez Carlos J, Sanchez-Perez Isabel, Gil-Mascarell Rosario, Rodríguez-Afonso Abigail, Torres Armando, Perona Rosario, Murguia José R

Abstract excerpt

The immunosuppressant Tacrolimus (FK506) has increased the survival rates of organ transplantation. FK506 exerts its immunosuppressive effect by inhibition of the protein phosphatase calcineurin in activated T-cells. Unfortunately, FK506 therapy is associated with undesired non-therapeutic effects involving targets other than calcineurin. To identify these targets we have addressed FK506 cellular toxicity in...

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PMID: 12813040
DOI: 10.1074/jbc.M305220200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.PMID 12813040Read ↗

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