Article
Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cerevisiae.
Journal of general microbiology - 1 Dec 1993
Parent S A, Nielsen J B, Morin N, Chrebet G, Ramadan N, Dahl A M, Hsu M J, Bostian K A, Foor F
Abstract excerpt
The immunosuppressants FK506 and cyclosporin A (CsA) bound to their receptors, FKBP12 or cyclophilin, inhibit the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, preventing T cell activation or, in yeast, recovery from alpha-mating factor arrest. Vegetative growth of yeast does not re...
Topics
- Amino Acid Isomerases
- Calcineurin
- Calcium
- Calmodulin-Binding Proteins
- Carrier Proteins
- Cyclosporine
- Drug Resistance, Microbial
- Genes, Fungal
- Heat-Shock Proteins
- Mutation
- Peptidylprolyl Isomerase
- Phenotype
- Phosphoprotein Phosphatases
- Saccharomyces cerevisiae
- Tacrolimus
- Tacrolimus Binding Proteins