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Article

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Clinical pharmacology and therapeutics - 1 Jun 2003

Nishizato Yohei, Ieiri Ichiro, Suzuki Hiroshi, Kimura Miyuki, Kawabata Kiyoshi, Hirota Takeshi, Takane Hiroshi, Irie Shin, Kusuhara Hiroyuki, Urasaki Yoko, Urae Akinori, Higuchi Shun, Otsubo Kenji, Sugiyama Yuichi

Abstract excerpt

OBJECTIVE: Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokinetics of pravastatin. METHODS: Genetic polymorphisms were screened by polymerase chain reaction-single-strand conformation polymorphism analysis, after sequencing with...

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PMID: 12811365
DOI: 10.1016/S0009-9236(03)00060-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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