Article
Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia.
Molecular psychiatry - 1 May 2003
Hallmayer J F, Jablensky A, Michie P, Woodbury M, Salmon B, Combrinck J, Wichmann H, Rock D, D'Ercole M, Howell S, Dragović M, Kent A
Abstract excerpt
As schizophrenia is genetically and clinically heterogeneous, systematic investigations are required to determine whether ICD-10 or DSM-IV categorical diagnoses identify a phenotype suitable and sufficient for genetic research, or whether correlated phenotypes incorporating neurocognitive performance and personality traits provide a phenotypic characterisation that accounts better for the underlying variation. We...
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