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Article

Discovering schizophrenia endophenotypes in randomly ascertained pedigrees.

Biological psychiatry - 1 Jan 2015

Glahn David C, Williams Jeff T, McKay D Reese, Knowles Emma E, Sprooten Emma, Mathias Samuel R, Curran Joanne E, Kent Jack W, Carless Melanie A, Göring Harald H H, Dyer Thomas D, Woolsey Mary D, Winkler Anderson M, Olvera Rene L, Kochunov Peter, Fox Peter T, Duggirala Ravi, Almasy Laura, Blangero John

Abstract excerpt

BACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes. Endophenotypes, traits genetically correlated with an illness, can help characterize the impact of risk genes by providing genetically relevant traits that are more tractable than the behavioral symptoms that...

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Identifiers

PMID: 25168609
DOI: 10.1016/j.biopsych.2014.06.027
PMCID: PMC4261014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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