Article
The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypes.
Schizophrenia bulletin - 1 Jan 2007
Gur Raquel E, Calkins Monica E, Gur Ruben C, Horan William P, Nuechterlein Keith H, Seidman Larry J, Stone William S
Abstract excerpt
The Consortium on the Genetics of Schizophrenia (COGS) is a 7-site collaboration that examines the genetic architecture of quantitative endophenotypes in families with schizophrenia. Here we review the background and rationale for selecting neurocognitive tasks as endophenotypic measures in genetic studies. Criteria are outlined for the potential of measures as endophenotypic vulnerability markers. These include...
Topics
- Cognition Disorders
- Cooperative Behavior
- Feasibility Studies
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Humans
- Multicenter Studies as Topic
- Neuropsychological Tests
- Phenotype