Article
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003
Schmidt-Kittler Oleg, Ragg Thomas, Daskalakis Angela, Granzow Martin, Ahr Andre, Blankenstein Thomas J F, Kaufmann Manfred, Diebold Joachim, Arnholdt Hans, Muller Peter, Bischoff Joachim, Harich Detlev, Schlimok Gunter, Riethmuller Gert, Eils Roland, Klein Christoph A
Abstract excerpt
According to the present view, metastasis marks the end in a sequence of genomic changes underlying the progression of an epithelial cell to a lethal cancer. Here, we aimed to find out at what stage of tumor development transformed cells leave the primary tumor and whether a defined genotype corresponds to metastatic disease. To this end, we isolated single disseminated cancer cells from bone marrow of breast...
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