Article
Prognostic value of genomic alterations in minimal residual cancer cells purified from the blood of breast cancer patients.
British journal of cancer - 1 Dec 2000
Austrup F, Uciechowski P, Eder C, Böckmann B, Suchy B, Driesel G, Jäckel S, Kusiak I, Grill H J, Giesing M
Abstract excerpt
The prognostic value of disseminated tumour cells derived from 353 breast cancer patients was evaluated. Disseminated tumour cells were purified from blood using a newly established method and nucleic acids were subsequently isolated. We investigated genomic imbalances (GI) such as mutation, amplification and loss of heterozygosity of 13 tumour suppressor genes and 2 proto-oncogenes using DNA from isolated...
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