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Article

Role of fibrillin-2 in the control of TGF-β activation in tumor angiogenesis and connective tissue disorders.

Biochimica et biophysica acta. Reviews on cancer - 1 Apr 2020

van Loon Karlijn, Yemelyanenko-Lyalenko Julia, Margadant Coert, Griffioen Arjan W, Huijbers Elisabeth J M

Abstract excerpt

Fibrillins constitute a family of large extracellular glycoproteins which multimerize to form microfibrils, an important structure in the extracellular matrix. It has long been assumed that fibrillin-2 was barely present during postnatal life, but it is now clear that fibrillin-2 molecules form the structural core of microfibrils, and are masked by an outer layer of fibrillin-1. Mutations in fibrillins give rise...

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PMID: 32119940
DOI: 10.1016/j.bbcan.2020.188354

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