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Article

Early fibrillin-1 assembly monitored through a modifiable recombinant cell approach.

Biomacromolecules - 14 Apr 2014

Hubmacher Dirk, Bergeron Eric, Fagotto-Kaufmann Christine, Sakai Lynn Y, Reinhardt Dieter P

Abstract excerpt

Fibrillin proteins constitute the backbone of extra-cellular macromolecular microfibrils. Mutations in fibrillins cause heritable connective tissue disorders, including Marfan syndrome, dominant Weill-Marchesani syndrome, and stiff skin syndrome. Fibronectin provides a critical scaffold for microfibril assembly in cell culture models. Full length recombinant fibrillin-1 was expressed by HEK 293 cells, which...

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Identifiers

PMID: 24559401
DOI: 10.1021/bm5000696
PMCID: PMC4961472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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