New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies.

doi:10.1042/BJ20151108

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Article

New insights into the structure, assembly and biological roles of 10-12 nm connective tissue microfibrils from fibrillin-1 studies.

The Biochemical journal - 1 Apr 2016

Jensen Sacha A, Handford Penny A

Abstract excerpt

The 10-12 nm diameter microfibrils of the extracellular matrix (ECM) impart both structural and regulatory properties to load-bearing connective tissues. The main protein component is the calcium-dependent glycoprotein fibrillin, which assembles into microfibrils at the cell surface in a highly regulated process involving specific proteolysis, multimerization and glycosaminoglycan interactions. In higher...

Topics

Animals
Connective Tissue
Dwarfism
Extracellular Matrix
Fibrillin-1
Fibrillins
Humans
Marfan Syndrome
Microfibrils
Microfilament Proteins
Mutation
Osteochondrodysplasias
Transforming Growth Factor beta

Source

Open in PubMed

Identifiers

PMID: 27026396
DOI: 10.1042/BJ20151108

Genes

FBN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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