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Article

Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2003

Pigino Gustavo, Morfini Gerardo, Pelsman Alejandra, Mattson Mark P, Brady Scott T, Busciglio Jorge

Abstract excerpt

Several lines of evidence indicate that alterations in axonal transport play a critical role in Alzheimer's disease (AD) neuropathology, but the molecular mechanisms that control this process are not understood fully. Recent work indicates that presenilin 1 (PS1) interacts with glycogen synthase kinase 3beta (GSK3beta). In vivo, GSK3beta phosphorylates kinesin light chains (KLC) and causes the release of...

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Identifiers

PMID: 12805290
PMCID: PMC6740780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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