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Article

The presenilin loop region is essential for glycogen synthase kinase 3 β (GSK3β) mediated functions on motor proteins during axonal transport.

Human molecular genetics - 1 Sept 2018

Banerjee Rupkatha, Rudloff Zoe, Naylor Crystal, Yu Michael C, Gunawardena Shermali

Abstract excerpt

Neurons require intracellular transport of essential components for function and viability and defects in transport has been implicated in many neurodegenerative diseases including Alzheimer's disease (AD). One possible mechanism by which transport defects could occur is by improper regulation of molecular motors. Previous work showed that reduction of presenilin (PS) or glycogen synthase kinase 3 beta (GSK3β)...

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Identifiers

PMID: 29790963
DOI: 10.1093/hmg/ddy190
PMCID: PMC6097159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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