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Article

PON1 haplotypes show genotype-dependent associations with dysglycemia and metabolic liver risk beyond paraoxonase activity.

Frontiers in endocrinology - 1 Jan 2026

Batista-Herrera Laura, Meneses Maria João, Ribeiro Rogério T, Gardete-Correia Luís, Raposo João F, Boavida José Manuel, Penha-Gonçalves Carlos, Macedo Maria Paula

Abstract excerpt

Introduction: Paraoxonase 1 (PON1) is a liver-derived HDL-associated enzyme with key antioxidant functions implicated in cardiometabolic disease. Genetic variation in PON1 strongly influences enzyme activity; however, whether specific genetic configurations contribute to dysglycemia and metabolic liver risk beyond enzymatic activity remains unclear. Methods: We analyzed 922 individuals from the PREVADIAB2 cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42483670
DOI: 10.3389/fendo.2026.1870186
PMCID: PMC13385122

Genes

PON1

Variants

rs2057681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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