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Article

Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin.

Oncogene - 26 Aug 2004

Robanus-Maandag Els, Giovannini Marco, van der Valk Martin, Niwa-Kawakita Michiko, Abramowski Vincent, Antonescu Cristina, Thomas Gilles, Berns Anton

Abstract excerpt

Previously, we have mimicked human neurofibromatosis type 2 (NF2) in conditional Nf2 mutant (P0Cre;Nf2flox2/flox2) mice. Schwannomas, characteristic for NF2, were found at low frequency in older mice. Here, we report that these mice, upon additional hemizygosity for p53, rapidly develop multiple tumours showing features consistent with malignant peripheral nerve sheath tumours. Thus, p53 hemizygosity promotes...

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Identifiers

PMID: 15221010
DOI: 10.1038/sj.onc.1207858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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