Article
Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction.
European heart journal - 1 Jun 2013
Jørgensen Anders Berg, Frikke-Schmidt Ruth, West Anders Sode, Grande Peer, Nordestgaard Børge G, Tybjærg-Hansen Anne
Abstract excerpt
AIMS: Elevated non-fasting triglycerides mark elevated levels of remnant cholesterol. Using a Mendelian randomization approach, we tested whether genetically increased remnant cholesterol in hypertriglyceridaemia due to genetic variation in the apolipoprotein A5 gene (APOA5) associates with an increased risk of myocardial infarction (MI). METHODS AND RESULTS: We resequenced the core promoter and coding regions of...
Topics
- Adult
- Aged
- Aged, 80 and over
- Apolipoprotein A-V
- Apolipoproteins A
- Case-Control Studies
- Cholesterol
- Female
- Genotype
- Humans
- Hypertriglyceridemia
- Linkage Disequilibrium
- Lipoproteins
- Male