Article
Mutations in the lipoprotein lipase gene associated with ischemic heart disease in men. The Copenhagen city heart study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 1999
Wittrup H H, Tybjaerg-Hansen A, Steffensen R, Deeb S S, Brunzell J D, Jensen G, Nordestgaard B G
Abstract excerpt
The aim of this study was to test the hypothesis that the Asp9Asn substitution and the T(-93)-->G mutation in the promoter of the lipoprotein lipase gene affect plasma lipid levels and thereby the risk of ischemic heart disease (IHD). We genotyped 9033 men and women from a general population sample and 940 patients with IHD. The frequency of both the G allele and the Asn9 allele in the general population sample...
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